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Description

These dysregulated dynamicsa common hallmark across neurodegenerative disorders, including Alzheimers, Parkinson's, and Huntington's diseases, lead to mitochondrial fragmentation, reduced bioenergetic efficiency, and elevated oxidative stress (37)

Itaconate activates the nuclear factor erythroid factor 2 (NRF2) pathway via Kelch-like erythroid cell-derived homology-associated protein 1 (KEAP1) alkylation, suppressing NLRP3 inflammasomes and promoting anti-inflammatory responses